Abstract

Background and Objectives: The prevention of lymphoceles was tested using collagen patch coated with the human coagulation factors (TachoSil) on 58 consecutive patients with endometrial cancer who had undergone hysterectomy and pelvic lymphadenectomy (PL). Methods: Patients were randomized in two groups: standard technique plus TachoSil (30 patients, group 1) and standard technique only (28, group 2). All surgical parameters were collected and patients underwent ultrasound examination on postoperative days 7, 14, and 28. The main outcome measures were: the development of symptomatic or asymptomatic lymphoceles, the need for further surgical intervention, as adverse effect of surgery and the drainage volume and duration. Results: Same number of lymph nodes in both groups was removed; group 1 showed a lower drainage volume. Lymphoceles developed in 7 patients in group 1 and 16 in group 2, but only 3 were symptomatic in group 1 and 9 symptomatic in group 2, with statistical difference. Percutaneous drainage proved necessary in five cases: only one was in group 1 and four in group 2. Conclusions: Intraoperative application of TachoSil reduced rate of postoperative lymphocysts after PL, and it seems to provide a useful additional treatment option for reducing drainage volume and preventing lymphocele development after PL.

Autore Pugliese

• Guido Marcello

Tutti gli autori

• Tinelli A. , Giorda G. , Manca C. , Pellegrino M. , Prudenzano R. , Guido M. , Dell'Edera D. , Malvasi A.

Titolo volume/Rivista

JOURNAL OF SURGICAL ONCOLOGY

Anno di pubblicazione

2012

ISSN

0022-4790

ISBN

Non Disponibile

Numero di citazioni Wos

10

Ultimo Aggiornamento Citazioni

23/04/2018

Numero di citazioni Scopus

13

Ultimo Aggiornamento Citazioni

23/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile