Abstract

The efficient internalization of TGF-beta inhibitor-loaded polyelectrolyte capsules and particles is studied in two HCC cell lines. Two polyelectrolyte pairs (biocompatible but not degradable and biodegradable crosslinked with gluteraldehyde) are employed for coating. The capsules are characterized by SEM. LY is successfully loaded inside the core and embedded between polymer layers. MS is used to quantify the loading efficiency by comparing post-loading and core-loading methods, since both coated templates and hollow shells are used as carriers. CLSM confirms dissolution of the pre-formed multilayer upon enzymatic degradation as the method of release, and migration assays demonstrate a higher inhibition efficiency of TGF-beta in tailored biodegradable capsules compared to free LY administration.

Autore Pugliese

• Vergaro Viviana , Ciccarella Giuseppe , Rinaldi Rosaria

Tutti gli autori

• F. Baldassarre , V. Vergaro , F. Scarlino , F. De Santis , G. Lucarelli , A. della Torre , G. Ciccarella , R. Rinaldi , G. Giannelli , S. Leporatti

Titolo volume/Rivista

MACROMOLECULAR BIOSCIENCE

Anno di pubblicazione

2012

ISSN

1616-5195

ISBN

Non Disponibile

Numero di citazioni Wos

18

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

17

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile