Abstract

In this work we propose a new technological approach aimed at improving the performances of DNA-chips in terms of detection sensitivity, signal-to-noise ratio and parallel analyses (spatial and spectral). It is based on the efficient enhancement of markers fluorescence through the insertion of photonic crystal nanocavities (PhC) in DNA-chips, thus giving higher sensitivity and allowing detection of small amounts of target biomolecules in the investigated solution. Moreover, this strategy univocally associates a specific emission wavelength to a specific nanocavity (and to the bio-probe immobilized on it), therefore allowing to infer the presence of a determined element in the solution by a simple spectral analysis of the optical response of the read-out region. This guarantees parallel detection of multiple elements and faster analysis time. The proposed 2D-PhC cavity assisted bio-chip read-out can be easily extended from DNA to a wide range of biomolecules, such as proteins, antibodies, aptamers, receptors.

Autore Pugliese

• De Vittorio Massimo

Tutti gli autori

• F. Pisanello , L. Martiradonna , P.P. Pompa , T. Stomeo , A. Qualtieri , G. Vecchio , S. Sabella , M. De Vittorio

Titolo volume/Rivista

MICROELECTRONIC ENGINEERING

Anno di pubblicazione

2010

ISSN

0167-9317

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile