Abstract

Carbohydrate polimeric microcapsules were assembled using a LbL approach onto a CaCO3 core. The microcapsules were used to delivery the anticancer drug cisplatin into HeLa and MCF-7 cancer cell lines. Drug encapsulation, measured by ICP spectroscopy, was around 50% of the charging solution. Fluorimetric measurements showed an efficient cellular uptake of polysacchardic microcapsules in both cell lines. The drug-loaded capsules demonstrated a better efficiency against cell viability than the free drug. Specifically, the amount of platinum reaching genomic DNA was measured, showing that encapsulation improves the nuclear delivery of the drug for both cell lines.

Autore Pugliese

• Ciccarella Giuseppe , Vergaro Viviana , Papadia Paride , Fanizzi Francesco Paolo

Tutti gli autori

• Vergaro V. , Papadia P. , Petrini P. , Fanizzi F.P. , De Pascali S. A. , Baldassarre F. , Pastorino L. , Ciccarella G.

Titolo volume/Rivista

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Anno di pubblicazione

2017

ISSN

0141-8130

ISBN

Non Disponibile

Numero di citazioni Wos

11

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

4

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile