Abstract

Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions caused by fat deposition within liver cells. Liver fat content reflects the equilibrium between several metabolic pathways involved in triglyceride synthesis and disposal, such as lipolysis in adipose tissue and de novo lipogenesis, triglyceride esterification, fatty acid oxidation and very-low-density lipoprotein synthesis/secretion in hepatic tissue. In particular, it has been demonstrated that the hepatic de novo lipogenesis plays a significant role in NAFLD pathogenesis. It is widely known that the fatty acid composition of the diet influences hepatic lipogenesis along with other metabolic pathways. Therefore, dietary fat may not only be involved in the pathogenesis of hepatic steatosis, but may also prevent and/or reverse hepatic fat accumulation. In this review major literature data about the role of some dietary fats as a potential cause of hepatic fat accumulation or as a potential treatment for NAFLD are described. Moreover, biochemical mechanisms responsible for the increase or the decrease in the hepatic lipid content are critically analyzed. It is noteworthy that both quantitative and qualitative aspects of dietary fat influence triglyceride deposition in liver. A high-fat diet or the dietary administration of conjugated linoleic acids induced hepatic steatosis. On the contrary, supplementation of the diet with krill oil or pine nut oil helped in the prevention and/or in the treatment of steatotic liver. Quite interesting is the “case” of olive oil, since several studies have often provided different and⁄∕or conflicting results in animal models.

Autore Pugliese

• Zara Vincenzo , Ferramosca Alessandra

Tutti gli autori

• Ferramosca A. , Zara V.

Titolo volume/Rivista

WORLD JOURNAL OF GASTROENTEROLOGY

Anno di pubblicazione

2014

ISSN

1007-9327

ISBN

Non Disponibile

Numero di citazioni Wos

41

Ultimo Aggiornamento Citazioni

22/04/2018

Numero di citazioni Scopus

44

Ultimo Aggiornamento Citazioni

24/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile