Abstract

Quercetin belongs to the chemical class of flavonoids and can be found in many common foods, such as apples, nuts, berries, etc. It has been demonstrated that quercetin has a wide array of biological effects that are considered beneficial to health treatment, mainly as anticancer. However, therapeutic applications of quercetin have been restricted to oral administration due to its sparing solubility in water and instability in physiological medium. A drug delivery methodology was proposed in this work to study a new quercetin release system in the form of magnetite–quercetin–copolymer (MQC). These materials were characterized through XRD, TEM, IR, and Thermal analysis. In addition, the magnetization curves and quercetin releasing experiments were performed. It was observed a nanoparticle average diameter of 11.5 and 32.5 nm at Fe3O4 and MQC, respectively. The presence of magnetic nanoparticles in this system offers the promise of targeting specific organs within the body. These results indicate the great potential for future applications of the MQC to be used as a new quercetin release system.

Autore Pugliese

• Mele Giuseppe Agostino

Tutti gli autori

• BARRETO A. C. H. , SANTIAGO V. R. , MAZZETTO S. E. , DENARDIN J. C. , LAVI´N R. , MELE G. , RIBEIRO M. E. N. P. , VIEIRA I. G. P. , GONCALVES T. , RICARDO N. M. P. S. , FECHINE P. B. A.

Titolo volume/Rivista

JOURNAL OF NANOPARTICLE RESEARCH

Anno di pubblicazione

2011

ISSN

1388-0764

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

33

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile