Abstract

The effects of an exposure to cadmium chloride 0.47 μM for 150 days were studied in kidneys of juveniles Sparus aurata by a multidisciplinary approach so to correlate uptake and detoxification potential to changes in brush border and glycocalyx sugar composition. Results demonstrated that cadmium concentration in kidney significantly increased from day 30 reaching a plateau on day 120 while metallothioneins reached a peak on day 90 and by day 120 were already decreasing to control values. Cytological damage was extensive on day 90, clearly detectable at both structural and ultrastructural levels, in tubular cells and brush-border. Staining with a panel of four lectins revealed a significant increase in N-Ac-Gal and a decrease in mannose in the glycocalyx and the tubular basal membranes. From day 120, when cadmium concentration was high and metallothionein concentration decreasing, a clear recovery was observed in tubular cells morphology and sugar composition. Possible significance of these apparently contrasting data are discussed.

Autore Pugliese

• Creti' Patrizia , Montinari Maria Rosa

Tutti gli autori

• Avallone B. , Cerciello R. , Cretì P. , Pizzoleo C. , Scudiero R. , Tizzano M. , Panzuto R. , Simoniello P. , Montinari M.R. , Motta C.M.

Titolo volume/Rivista

AQUATIC TOXICOLOGY

Anno di pubblicazione

2017

ISSN

0166-445X

ISBN

Non Disponibile

Numero di citazioni Wos

1

Ultimo Aggiornamento Citazioni

25/04/2018

Numero di citazioni Scopus

1

Ultimo Aggiornamento Citazioni

24/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile