Abstract

The sonication-assisted layer-by-layer (SLBL) technology was developed to combine necessary factors for an efficient drug-delivery system: (i) control of nanocolloid size within 100 - 300 nm, (ii) high drug content (70% wt), (iii) shell biocompatibility and biodegradability, (iv) sustained controlled release, and (v) multidrug-loaded system. Stable nanocolloids of Paclitaxel (PTX) and lapatinib were prepared by the SLBL method. In a multidrug-resistant (MDR) ovarian cancer cell line, OVCAR-3, lapatinib/PTX nanocolloids mediated an enhanced cell growth inhibition in comparison with the PTX-only treatment. A series of in vitro cell assays were used to test the efficacy of these formulations. The small size and functional versatility of these nanoparticles, combined with their ability to incorporate various drugs, indicates that lapatinib/PTX nanocolloids may have in vivo therapeutic applications.

Autore Pugliese

• Vergara Daniele , Maffia Michele , Rinaldi Rosaria , Vergaro Viviana

Tutti gli autori

• D. VERGARA , C. BELLOMO , X. ZHANG , V. VERGARO , A. TINELLI , V. LORUSSO , R. RINALDI , Y.M. LVOV , S. LEPORATTI , M. MAFFIA

Titolo volume/Rivista

NANOMEDICINE

Anno di pubblicazione

2012

ISSN

1549-9634

ISBN

Non Disponibile

Numero di citazioni Wos

35

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

38

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile