Abstract

Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals <3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals <3 years.

Autore Pugliese

• Devoti Gabriele

Tutti gli autori

• Cardwell C.R. , Svensson J. , Waldhoer T. , Ludvigsson J. , Sadauskaité-Kuehne V. , Roberts C.L. , Parslow R.C. , Wadsworth E.J. , Brigis G. , Urbonaité B. , Schober E. , Devoti G. , Ionescu-Tirgoviste C. , de Beaufort C.E. , Patterson C.C.

Titolo volume/Rivista

DIABETES

Anno di pubblicazione

2012

ISSN

0012-1797

ISBN

Non Disponibile

Numero di citazioni Wos

7

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

7

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile