Abstract

The aim of the present work is to study the influence of the precipitation temperature in the synthesis of nanohydroxyapatite (n-HAp) on the properties of the resulting n-HAp powder for the fabrication of highly porous scaffolds for bone tissue engineering. The n-HAp powder was obtained by a wet precipitation technique starting from calcium nitrate tetrahydrate (Ca(NO3)(2)*4H(2)O) and phosphoric acid (H3PO4) at different temperatures: 10 degrees C, 37 degrees C and 50 degrees C. Highly porous scaffolds were fabricated using the three different powders by the sponge replica method and sintering at 1300 degrees C. Combined X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses on powders indicated that on increasing the precipitation temperature the formation of pure n-HAp is accelerated, without significant changes in particles morphology and size. Scaffolds characterized by high porosity (89%) and good compressive strength (0.53 MPa for n-HAp prepared at 37 degrees C) were obtained. XRD analyses on sintered n-HAp confirmed the thermal stability of the material. Therefore, the as-synthesized n-HAp powder can be successfully used for the fabrication of highly porous scaffolds as bone substitutes.

Autore Pugliese

• Sannino Alessandro , Scalera Francesca , Gervaso Francesca , Cozzoli Pantaleo Davide

Tutti gli autori

• Parisi C. , Gervaso F. , Scalera F. , Padmanabhan S.K. , Nobile C. , Cozzoli P.D. , Di Silvio L. , Sannino A.

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Anno di pubblicazione

2014

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Numero di citazioni Wos

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Settori ERC

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