Harmonic Ultrasound Imaging of Nanosized Contrast Agents for Multimodal Molecular Diagnoses

Abstract

The aim of the present work was to demonstrate the possibility of selective detection of nanoparticle contrast agents (NPCAs) on diagnostic echographic images by exploiting the second harmonic component they introduce in the spectra of corresponding ultrasound signals, as a consequence of nonlinear distortion during ultrasound propagation. We employed silica nanospheres (SiNSs) of variable diameter (160 nm, 330 nm, and 660 nm) dispersed in different volume concentrations (range 0.07–0.8%) in agarose gel samples that were automatically scanned through a digital ecograph using narrow-band ultrasound pulses at 6.6 MHz and variable mechanical index (MI range 0.2–0.6).


Tutti gli autori

  • F. CONVERSANO , A. GRECO , E. CASCIARO , A. RAGUSA , A. LAY EKUAKILLE , S. CASCIARO

Titolo volume/Rivista

IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT


Anno di pubblicazione

2012

ISSN

0018-9456

ISBN

Non Disponibile


Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile


Numero di citazioni Scopus

37

Ultimo Aggiornamento Citazioni

28/04/2018


Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile