Abstract

Halloysite is natural aluminosilicate clay with hollow tubular structure which allows loading with low soluble drugs using their saturated solutions in organic solvents. Resveratrol, a polyphenol known for having antioxidant and antineoplastic properties, is loaded inside these clay nanotubes lumens. Release time of 48 h is demonstrated. Spectroscopic and ζ-potential measurements are used to study the drug loading/release and for monitoring the nanotube layer-by-layer (LbL) coating with polyelectrolytes for further release control. Resveratrol-loaded clay nanotubes are added to breast cell cultures for toxicity tests. Halloysite functionalization with LbL polyelectrolyte multilayers remarkably decrease nanotube self-toxicity. MTT measurements performed with a neoplastic cell lines model system (MCF-7) as function of the resveratrol-loaded nanotubes concentration and incubation time indicate that drug-loaded halloysite strongly increase of cytotoxicity leading to cell apoptosis.

Autore Pugliese

• Vergaro Viviana

Tutti gli autori

• Vergaro V. , Lvov Y.M. , Leporatti S.

Titolo volume/Rivista

MACROMOLECULAR BIOSCIENCE

Anno di pubblicazione

2012

ISSN

1616-5187

ISBN

Non Disponibile

Numero di citazioni Wos

74

Ultimo Aggiornamento Citazioni

27/04/2018

Numero di citazioni Scopus

82

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile