Abstract

The immune system is essential to maintain the mutualistic homeostatic interaction between the host and its micro- and mycobiota. Living as a commensal,Saccharomyces cerevisiaecould potentially shape the immune response in a significant way. We observed thatS. cerevisiaecells induce trained immunity in monocytes in a strain-dependent manner through enhanced TNFα and IL-6 production upon secondary stimulation with TLR ligands, as well as bacterial and fungal commensals. Differential chitin content accounts for the differences in training properties observed among strains, driving induction of trained immunity by increasing cytokine production and direct antimicrobial activity bothin vitroandin vivo These chitin-induced protective properties are intimately associated with its internalization, identifying a critical role of phagosome acidification to facilitate microbial digestion. This study reveals how commensal and passenger microorganisms could be important in promoting health and preventing mucosal diseases by modulating host defense toward pathogens and thus influencing the host microbiota-immune system interactions.

Autore Pugliese

• Lenucci Marcello Salvatore

Tutti gli autori

• Rizzetto L. , Ifrim D.C. , Moretti S. , Tocci N. , Cheng S.C. , Quintin J. , Renga G. , Oikonomou V. , De Filippo C. , Weil T. , Blok B.A. , Lenucci M.S. , Santos M.A.S. , Romani L. , Netea M.G. , Cavalieri D.

Titolo volume/Rivista

THE JOURNAL OF BIOLOGICAL CHEMISTRY

Anno di pubblicazione

2016

ISSN

0021-9258

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

12

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile