Abstract

The Radio Frequency Identification (RFID) technology promises to improve several processes in the healthcare scenario, especially those related to traceability of people and things. Unfortunately, there are still some barriers limiting the large-scale deployment of these innovative technologies in the healthcare field. Among these, the evaluation of potential thermal and non-thermal effects due to the exposure of biopharmaceutical products to electromagnetic fields is very challenging, but still slightly investigated. This paper aims to setup a controlled RF exposure environment, in order to reproduce a worst-case exposure of pharmaceutical products to the electromagnetic fields generated by the UHF RFID devices placed along the supply chain. Radiated powers several times higher than recommended by current normative limits were applied (10 W and 20 W). The electric field strength at the exposed sample location, used in tests, was as high as 100 V/m. Non-thermal effects were evaluated by chromatography techniques and in vitro assays. The results obtained for a particular case study, the ActrapidTM human insulin preparation, showed temperature increases lower than 0.5°C and no significant changes in the structure and performance of the considered drug.

Autore Pugliese

• Mainetti Luca , Patrono Luigi , Maffia Michele

Tutti gli autori

• G. CALCAGNINI , F. CENSI , M. MAFFIA , L. MAINETTI , E. MATTEI , L. PATRONO , E. URSO

Titolo volume/Rivista

IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE

Anno di pubblicazione

2012

ISSN

1089-7771

ISBN

Non Disponibile

Numero di citazioni Wos

12

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

19

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile