Abstract

In this paper we describe the one-pot fabrication of hydroxyapatite (HA)-heparin composites by electrodeposition onto Ti substrates and their characterisation in terms of structure, morphology, heparin content and bioactivity. HA coatings are well known and widely applied osteointegration enhancers, but post-implant healing rate in dental applications is still suboptimal: e.g. coagulation control plays a key role and the incorporation of an anticoagulant is considered a highly desirable option. In this study, we have developed an improved, simple and robust growth procedure for single-phase, pure HA-heparin films of thickness 1/3 l m. HA-heparin, forming nanowires, has the ideal morphology for bone mineralisation. Staining assays revealed homogeneous incorporation of sizable amounts of heparin in the composite films. The bioactivities of the HA and HA-heparin coatings on Ti were compared by HeLa cell proliferation/viability tests and found to be enhanced by the presence of the anticoagulant.

Autore Pugliese

• Verri Tiziano , Mele Claudio , Bozzini Benedetto

Tutti gli autori

• B. Bozzini , A. Barca , F. Bogani , M. Boniardi , P. Carlino , C. Mele , T. Verri , A. Romano

Titolo volume/Rivista

JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE

Anno di pubblicazione

2014

ISSN

0957-4530

ISBN

Non Disponibile

Numero di citazioni Wos

4

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

7

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile