DIETARY ANTIOXIDANT POLYPHENOLS REDUCE INFLAMMATORY ANGIOGENESIS THROUGH MMP-9 AND COX-2 INHIBITION: A POTENTIALLY PROTECTIVE MECHANISM IN ATHEROSCLEROTIC VASCULAR DISEASE AND CANCER.

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Abstract

Antioxidant phytochemicals, including the polyphenols from olive oil oleuropein (OE) and hydroxytyrosol (HT), and red wine antioxidant resveratrol (RSV) and quercetin (Q), are associated with low prevalence of cardiovascular diseases and cancer. Angiogenesis is a key process both in cancer and atherosclerosis, and is tightly regulated by molecular mediators including reactive oxygen species (ROS), cyclooxygenase (COX)-2 and matrix metalloproteinases (MMPs). We studied the effects of olive oil and red wine antioxidants on the angiogenic potential in an in vitro model of angiogenesis, and explored underlying mechanisms.

Autore Pugliese

Tutti gli autori

  • M.A. Carluccio , E. Scoditti , N. Calabriso , M. Massaro , A. Tinelli , M.R. Montinari , C. Storelli , R. De Caterina.

Titolo volume/Rivista

JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS

Anno di pubblicazione

2010

ISSN

1661-6499

ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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