Chitosan-based scaffolds exhibit modular features induced by magnetic nanoparticles and L-arginine amino acid

Abstract

Large bone or osteochondral defects still need new approaches to ameliorate the regeneration process. The integration of magnetic nanoparticles into synthetic/natural scaffold formulations, could lead to obtain a suitable, responsive “on demand” tool able to guide the regeneration process. The aim of this work was the design and characterization of chitosan-based scaffolds containing dextran-grafted maghemite (DM) with modular mechano-structural and biomimetic properties implemented by the presence of a bioactive agent such the L-arginine amino acid. Both components can act as modulators of the scaffold features and, at the same time, the simultaneous presence of MNPs and L-Arg can be exploited to induce variations with respect to the cytocompatibility responses.


Tutti gli autori

  • Scialla S. , Canoci R. , Barca A. , Palazzo B. , Scalera F. , Verri T. , Sannino A. , Gervaso F.

Titolo volume/Rivista

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Anno di pubblicazione

2016

ISSN

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Settori ERC

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Codici ASJC

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