Abstract

Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease. Viral persistence and pathogenesis rely mainly on the ability of HCV to deregulate specific host processes, including lipid metabolism and innate immunity. Recently, autophagy has emerged as a cellular pathway, playing a role in several aspects of HCV infection. This review summarizes current knowledge on the molecular mechanisms that link the HCV life cycle with autophagy machinery. In particular, we discuss the role of HCV/autophagy interaction in dysregulating inflammation and lipid homeostasis and its potential for translational applications in the treatment of HCV-infected patients.

Autore Pugliese

• Fimia Gian Maria

Tutti gli autori

• Vescovo T. , Refolo G. , Romagnoli A. , Ciccosanti F. , Corazzari M. , Alonzi T. , Fimia G.M.

Titolo volume/Rivista

BIOMED RESEARCH INTERNATIONAL

Anno di pubblicazione

2014

ISSN

2314-6141

ISBN

Non Disponibile

Numero di citazioni Wos

8

Ultimo Aggiornamento Citazioni

25/04/2018

Numero di citazioni Scopus

10

Ultimo Aggiornamento Citazioni

26/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile