Abstract

Receptors for the Fc fragment of immunoglobulin G (FcgammaRs) are important molecules not only to mediate and control the effectors' functions of IgG antibodies, but they also control the autoimmunity-tolerance balance in the periphery. In humans, three different types of FcgammaRs, belonging to the Ig gene superfamily, have been identified; FcgammaRI (cluster of differentiation (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16). A wide range of inflammatory and autoimmune diseases, such as vasculitis, glomerulonephritis, and autoimmune hemolytic anemia, seems to be mediated, in part, by FcgammaRs. Recent findings supposed that, under certain conditions, FcgammaRs are involved in the penetration of antibodies into cells and FcgammaRs constitute one of the main effector mechanisms through which autoantibodies exert their action. In this review, we concentrate on the role of human FcgammaRs in autoantibodies penetration and summarize the current knowledge on the structure, ligand binding capacity and their role in autoimmunity and pathogenic effect of autoantibodies.

Autore Pugliese

• Lofrumento Dario Domenico

Tutti gli autori

• Lisi S. , Sisto M. , Lofrumento D.D. , D'Amore S. , D'Amore M.

Titolo volume/Rivista

CLINICAL AND EXPERIMENTAL MEDICINE

Anno di pubblicazione

2011

ISSN

1591-8890

ISBN

Non Disponibile

Numero di citazioni Wos

11

Ultimo Aggiornamento Citazioni

25/04/2018

Numero di citazioni Scopus

12

Ultimo Aggiornamento Citazioni

26/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile