Abstract

The attraction of nucleic acids to lipidic compartments is the first step for carriers of potentially inheritable information to self-organise in functionalised synthetic cells. Confocal fluorescence imaging shows that a synthetic amphiphilic peptidyl RNA molecule spontaneously accumulates at the outer bilayer membranes of phospho- and glycolipidic giant vesicles. Cooperatively attractive interactions of −3.4 to −4.0 kcal mol−1 between a random coil hydrophobic peptide and lipid membranes can thus pilot lipophobic RNA to its compartmentation. The separation of mixed lipid phases in the membranes further enhances the local concentration of anchored RNA.

Autore Pugliese

• Stano Pasquale

Tutti gli autori

• Isaad A.L.C. , Carrara P. , Stano P. , Krishnakumar P. , Lafont K.S. , Zamboulis D. , Buchet A. , Bouchu R. , Albrieux D. , Strazewski F.

Titolo volume/Rivista

ORGANIC & BIOMOLECULAR CHEMISTRY

Anno di pubblicazione

2014

ISSN

1477-0520

ISBN

Non Disponibile

Numero di citazioni Wos

3

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

4

Ultimo Aggiornamento Citazioni

22/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile