Substituted Aminoalkyl- and Amidoalkyl-Benzopyran Derivatives

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Abstract

This invention is related to novel aminoalkyl- and amidoalkyl-benzopyran derivatives of the following general formula (I) wherein: the group is a substituent in position 6 or 7 wherein: R is an aromatic mono- or bi-cyclic carbocyclic ring or a mono- or bi-cyclic heterocyclic ring radical, said rings being optionally substituted by one or two substituents selected from (C1-C5) straight or branched alkyl, (C1-C5) straight or branched alkoxy, hydroxy, halogen and trifluoromethyl; m is zero or an integer from 1 to 3; n, p, R1 and R2 are as herein indicated and R3 and R4 are both hydrogen or taken together represent an oxygen atom, and the pharmaceutically acceptable salts thereof. The compounds that are active as selective and reversible MAO-B inhibitors in vitro and in vivo, are useful as medicaments for the prevention and the treatment of CNS degenerative disorders.

Classe Tecnologica

A - Human Necessities

Patent Office

United States Patent and Trademark Office

Numero Deposito

US2009005436

Anno Deposito

2006

Anno Concessione

2009

Inventori Pugliesi

  • Carotti Angelo

Tutti gli inventori

  • Angelo Carotti
  • Piero Melloni
  • Florian Thaler
  • Carla Caccia
  • Sara Maestroni
  • Patriciia Salvati

Titolari pugliesi

  • Non ci sono titolari pugliesi

Tutti i titolari

  • Newron Pharmaceutical S.p.a