Method of identifying a target analyte using photonic crystal resonators, and related device

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Abstract

A method of identifying target analytes in a sample, particularly a biological sample, comprising the steps of putting a plurality of target analytes, bound to a common luminescent marker, in contact with a plurality of molecular probes immobilized on a support, each of said molecular probes being capable of complementary binding to a respective target analyte, if said target analyte is present in the sample, providing to said support an excitation radiation and detecting an emission radiation coming from said support as a result of at least one complementary binding event, characterized by the fact that: said support comprises a plurality of photonic crystal resonators, at least two of said resonators being characterized by different resonance wavelengths; each of said molecular probes being fixed to a respective resonator;; and by the fact that the identification of at least one target analyte is carried out through the analysis of the total emission spectrum coming from said plurality of photonic crystals resonators, in order to detect possible wavelength resonance peaks generated as a result of the binding of said target analyte, bound to the common luminescent marker, to one or more of said molecular probes.

Classe Tecnologica

C - Chemistry and Metallurgy

Patent Office

United States Patent and Trademark Office

Numero Deposito

US8029994

Anno Deposito

2009

Anno Concessione

2010

Inventori Pugliesi

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  • Kanna Aoki
  • Massimo De Vittorio
  • Tiziana Stomeo
  • Ferruccio Pisanello
  • Alessandro Massaro
  • Luigi Martiradonna
  • Stefania Sabella
  • Rosaria Rinaldi
  • Yasuhiko Arakawa
  • Roberto Cingolani
  • Pier Paolo Pompa

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