GALACTOSYLATED PRO-DRUGS OF NON-STEROIDAL ANTI-INFLAMMATORIES WITH IMPROVED PHARMACOKINETIC CHARACTERISTICS AND REDUCED TOXICITY OF THE STARTING DRUG

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Abstract

Pro-drugs of all non-steroidal anti-inf lammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L- enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.

Classe Tecnologica

A - Human Necessities

Patent Office

United States Patent and Trademark Office

Numero Deposito

US2011212904

Anno Deposito

2008

Anno Concessione

2011

Inventori Pugliesi

  • Melisi Daniela

Tutti gli inventori

  • Maria Grazia Rimoli
  • Antonio Calignano
  • Rosario Cuomo
  • Gianpiero Boatto
  • Enrico Abignente
  • Daniela Melisi
  • Daniela Melisi
  • Annalisa Curcio
  • Elvira Luongo
  • Giovanna La Rana
  • Oscar Sasso
  • Giovanni Sarnelli
  • Roberto Russo
  • Maria Nieddu
  • Carla Cirillo
  • Salvatore De Lucia

Titolari pugliesi

  • Non ci sono titolari pugliesi

Tutti i titolari

  • Maria Grazia Rimoli
  • Antonio Calignano
  • Rosario Cuomo
  • Gianpiero Boatto
  • Stewart Italia S.r.l.