ANTIBODIES TO ENDOPLASMIN AND THEIR USE

Torna indietro

Abstract

Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.

Classe Tecnologica

A - Human Necessities

Patent Office

United States Patent and Trademark Office

Numero Deposito

US2012009194

Anno Deposito

2010

Anno Concessione

2012

Inventori Pugliesi

Tutti gli inventori

  • Soldano Ferrone
  • Xinhui Wang
  • Thomas P.condras
  • Elvira Favoino
  • Brian L.hood

Titolari pugliesi

  • Non ci sono titolari pugliesi

Tutti i titolari

  • University Of Pittsburg -of The Commonwealth System Of Higer Education