REPROGRAMMING-BASED MODELS OF NEURODEVELOPMENTAL DISORDERS AND USES THEREOF

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Abstract

The present invention relates to iPSC produced from fibroblast obtained from a subject affected by a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and uses thereof. The present invention also relates to a cortical neural progenitor cell or a terminally differentiated cortical glutamatergic or gabaergic neuronal cell or a neural crest stem cell line, a mesenchymal stem cell line produced from the iPSC or iPSC line. The invention also relates to method for identifying a compound for the treatment and/or prevention of a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and to a LSD1 inhibitor or a HDAC2 inhibitor for use in the treatment of such disorders.

Classe Tecnologica

C - Chemistry and Metallurgy

Patent Office

European Patent Office

Numero Deposito

EP 3224352

Anno Deposito

2015

Anno Concessione

2017

Inventori Pugliesi

  • Merla Giuseppe

Tutti gli inventori

  • Testa Giuseppe
  • Atashpazgargari Sina
  • Adamo Antonio
  • Germain Pierre-luc
  • Merla Giuseppe
  • D'agostino Giuseppe
  • Zanella Matteo

Titolari pugliesi

  • IRCCS Casa Sollievo Della Sofferenza

Tutti i titolari

  • IRCCS Casa Sollievo Della Sofferenza
  • IEO - Istituto Europeo Di Oncologia Srl
  • Universita' Degli Studi Di Milano