METHOD FOR IDENTIFYING HIGH-AFFINITY COMPLEXES OF TWO LIGANDS AND A RECEPTOR, DEVICE FOR CARRYING OUT THE METHOD AND SELF-ASSEMBLYING CHEMICAL LIBRARY FOR USE WITH SAID METHOD

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Abstract

The present invention relates to a method for the sensitive identification of high-affinity complexes of two ligands (2, 3, 4, 5, 6, 7) and a receptor (1). To this end, a plurality of different ligands (2, 3, 4, 5, 6, 7) of a chemical library are brought into contact with at least one receptor (1) in a solution. The ligands of the library have single-stranded DNA (8, 9) or RNA with a base length of 2 to 10 bases or, alternatively, more than 10 bases. The solution is incubated for a specified period of time and complexes of two ligands (2, 3, 4, 5, 6, 7) and a receptor (1) are identified.

Classe Tecnologica

C - Chemistry and Metallurgy

Patent Office

European Patent Office

Numero Deposito

EP 3169832

Anno Deposito

2015

Anno Concessione

2017

Inventori Pugliesi

  • Mele Elisa

Tutti gli inventori

  • Reddavide Francesco
  • De Andrade Helena
  • Lin Weilin
  • Zhang Yixin
  • Mele Elisa

Titolari pugliesi

  • Non ci sono titolari pugliesi

Tutti i titolari

  • Technische Universität Dresden