ALBUMIN NANOPARTICLES ENCAPSULATING GADOLINIUM AND METHOD OF SYNTHESIS THEREOF

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Abstract

The invention relates to cross-linked albumin nanoparticles loaded with gadolinium, for example with GdCl3 or Gd-DTPA, characterized in that they have a controlled size comprised between 50 nm and 80 nm, and that the gadolinium molecules are encapsulated by albumin, without the presence of covalent or electrostatic bonds. The gadolinium thus encapsulated has a relaxivity value greater than the reference molecules currently used for MRI diagnostics. The method of synthesis of the nanoparticles of the invention is also described.

Classe Tecnologica

A - Human Necessities

Patent Office

European Patent Office

Numero Deposito

EP 3233135

Anno Deposito

2015

Anno Concessione

2017

Inventori Pugliesi

  • Sabella Stefania
  • Malvindi Maria Ada
  • Pompa Pier Paolo

Tutti gli inventori

  • Sabella Stefania
  • Malvindi Maria Ada
  • Torino Enza
  • Pompa Pier Paolo
  • Cingolani Roberto
  • Netti Paolo

Titolari pugliesi

  • Non ci sono titolari pugliesi

Tutti i titolari

  • Fondazione Istituto Italiano Di Tecnologia